Methods and Compositions for Processes of Rapid Selection and Production of Nucleic Acid Aptamers

Serial Number: 9/273,345
Issued on March 1, 2016


Embodiments herein relate to compositions and methods for making and using aptamers, for example, DNA aptamers (DCEs) and/or RNA aptamers. In some embodiments, methods relate to making and amplifying target DCEs. In certain embodiments, methods for making capture elements or aptamers concern using a reporter moiety and signal reducing moiety prior to amplifying a target-specific capture element. In some embodiments, methods disclosed herein may be used to rapidly generate large quantities of aptamers such as DCEs directed to a particular target agent. Some embodiments relate to systems for performing automated generation of aptamers.

Original Filing Date – December 28, 2006

Inventors: Johnathan Kiel, Eric Holwitt, Michael Fan (Fan Maomian) and Shelly D. Roper

(Inventors bolded and italicized were CMI employees as of the date of filing)

Attributable to work performed by CMI under USAF Contract: F41624-03-D-7000-01.

US Patent

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