Patent-of 8-Nitroguanine 2004


Novel methods for the synthesis of 8-nitroguanine are provided. Compositions comprising 8-nitroguanine, made by the novel synthetic methods are also provided herein. Methods of use of 8-nitroguanine, made by the novel synthetic methods, as a standard for detection of 8-nitroguanine in samples are also encompassed within the scope of the present invention. The present invention further concerns methods of predicting organ transplant rejection and detecting exposure to environmental stressors, such as ionizing radiation, toxic chemicals or infectious agents, by detecting 8-nitroguanine in one or more samples from a transplant recipient or an organism exposed to stress.

Original Filing Date November 13, 2001.

Inventor: Eric Holwitt. (Inventor bolded and italicized was a CMI employee as of the date of filing.)

Eric Holwitt was employed by CMI from 13 May 1998 through 30 May 2003. Previous to 13 May 1998, Dr. Holwitt was Major in the Air Force; subsequent to 30 May 2003 Dr. Holwitt is employed as a government civilian working at Brooks City-Base, TX until early 2011 and currently at Wright-Patterson AFB, OH.

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